Abcam, ab122193, Anti-GLT25D2 antibody

Size: 100µL
Rabbit Polyclonal GLT25D2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human COLGALT2 aa 550 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human COLGALT2 aa 550 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8IYK4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GLT25D2 also known as Procollagen Galactosyltransferase 2 is an enzyme with a molecular mass of approximately 80 kDa. It functions by catalyzing the galactosylation of hydroxylysine residues in procollagen a critical step in collagen biosynthesis. GLT25D2 is expressed in various tissues including the skin and cartilage highlighting its involvement in extracellular matrix formation and maintenance.
Biological function summary
GLT25D2 plays a role in collagen maturation impacting tissue strength and stability. It is part of a larger complex involved in post-translational modifications. The enzyme acts on specific substrates ensuring proper cross-linking and stabilization of collagen fibers which are essential for maintaining structural integrity in connective tissues.
Pathways
The activity of GLT25D2 connects to the collagen biosynthesis and modification pathway impacting overall tissue morphology and function. It interacts with enzymes such as lysyl hydroxylase which also participates in collagen modification. These interactions underline its role in pathways that modulate tissue development and repair.
GLT25D2 has been linked to connective tissue disorders and osteoarthritis. Defects or alterations in its activity can compromise collagen stability leading to degenerative changes in tissues. Proteins like lysyl hydroxylase may also show altered expression in these conditions further contributing to disease pathology. Understanding GLT25D2's role may provide insights into therapeutic strategies for related conditions.