Abcam, ab122305, Anti-Leiomodin-3 antibody

Size: 100µL
Rabbit Polyclonal Leiomodin-3 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LMOD3 aa 150-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LMOD3 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.Q0VAK6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Leiomodin-3 often referred to as LMOD3 is a protein that plays an important role in the organization of actin filaments in muscle cells. Like other members in the leiomodin family it acts as an actin nucleator. LMOD3 with a molecular weight of approximately 64 kDa is mainly expressed in skeletal muscle tissues where it interacts with actin to promote assembly and stabilization of thin filaments. Understanding LMOD3 function is important for unraveling the underlying mechanisms of actin filament dynamics in muscle function.
Biological function summary
LMOD3 contributes to the precise structure and function of sarcomeres the basic contractile units in striated muscle cells. It is not known to be part of a larger protein complex but it interacts directly with actin filaments to facilitate their elongation. By enhancing proper thin filament length and configuration LMOD3 supports efficient muscle contraction and mechanical force generation. This regulation ensures that muscles maintain strength and structural integrity during repeated cycles of contraction and relaxation.
Pathways
The processes that LMOD3 influences are vital for muscle contraction and are closely linked to the actin-myosin interaction pathway. This pathway involves interactions with tropomyosin and troponin the proteins essential for calcium-dependent regulation of muscle contraction. Additionally LMOD3 shares functional similarities with proteins like tropomodulin which also is involved in actin filament capping and extension serving as a fine-tuning mechanism for controlling filament length in muscular tissues.
Mutations or deficiencies in LMOD3 have been implicated in nemaline myopathy a disorder characterized by muscle weakness and the presence of rod-like structures in muscle biopsies. Patients with disorders linked to LMOD3 often show symptoms due to disruptions in actin filament structure and muscle fiber instability. LMOD3 is also associated with nebulin-related pathologies as nebulin is another protein involved in thin filament regulation in muscle and disturbances in these pathways can contribute to similar muscular defects. Understanding the role of LMOD3 in these contexts provides insights into potential therapeutic approaches for muscle-related diseases.