Abcam, ab122312, Anti-Amelotin antibody

Size: 100µL
Rabbit Polyclonal Amelotin antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human AMTN aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human AMTN aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q6UX39

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Amelotin also known as AMTN is a protein involved in the formation and mineralization of dental enamel. The protein has an estimated mass of approximately 24 kilodaltons. It is expressed in high amounts in ameloblasts which are cells involved in dental enamel production especially in the maturation stage of enamel development.
Biological function summary
The protein encoded by the Amelotin gene plays a significant role in dental epithelial cell differentiation and enamel biomineralization. Amelotin does not appear to form part of a larger protein complex but acts in coordination with other enamel matrix proteins. Its expression increases as ameloblasts transition into maturation stage suggesting it modulates enamel matrix mineralization.
Pathways
The protein influences tooth development processes particularly within the amelogenesis pathway. Amelotin interacts with and complements the roles of other enamel matrix proteins such as amelogenin and enamelin. Its activity contributes to the regulation of calcium and phosphate ion deposition required for enamel hardening.
Malfunction or altered expression of Amelotin associates with amelogenesis imperfecta a disorder affecting enamel development. The interaction between Amelotin and enamelin may be important in understanding the pathophysiology of this condition. It is also implicated in carious lesions due to its potential impact on enamel resilience. Understanding Amelotin's function can offer insights into these dental health issues and point to therapeutic interventions.