Abcam, ab122481, Anti-OTUD1 antibody

Size: 100µL
Rabbit Polyclonal OTUD1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 17 publications. Immunogen corresponding to Recombinant Fragment Protein within Human OTUD1 aa 250-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human OTUD1 aa 250-400. The exact immunogen used to generate this antibody is proprietary information.Q5VV17

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
OTUD1 also known as OTU domain-containing protein 1 functions as a deubiquitinating enzyme. This protein exhibits a mass of approximately 50 kDa and importantly removes ubiquitin molecules from specific protein targets. Expression of OTUD1 occurs in various tissues with significant levels detected in the liver pancreas and lung. The presence in different tissues suggests its versatile roles in cellular processes.
Biological function summary
OTUD1 stabilizes proteins involved in cell signaling and immune responses. It participates in complexes that regulate cell proliferation and apoptosis indicating its importance in maintaining cellular homeostasis. Through its deubiquitinating action OTUD1 influences the degradation of proteins by the proteasome affecting key cellular pathways. Its interactions in these complexes highlight its regulatory significance in cellular dynamics.
Pathways
The function of OTUD1 integrates into the NF-kB signaling and DNA damage repair pathways. It interacts with proteins like TRAF6 and p53 modulating their stability and activity. The connection to NF-kB signaling implicates OTUD1 in regulating inflammatory responses while involvement in DNA damage repair associates it with genomic integrity maintenance. These interactions emphasize its role in significant cellular pathways.
Implications of OTUD1 relate to cancer and autoimmune diseases. Alterations in OTUD1 expression or function could contribute to tumor progression potentially through disrupted regulation of proteins like p53. Additionally its role in inflammatory responses has potential links to autoimmune disorders. Understanding its interaction with proteins involved in these conditions may provide insights into therapeutic strategies.