Abcam, ab122557, Anti-EHBP1L1 antibody

Size: 100µL
Rabbit Polyclonal EHBP1L1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human EHBP1L1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human EHBP1L1. The exact immunogen used to generate this antibody is proprietary information.Q8N3D4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The EHBP1L1 protein also known as EH domain binding protein 1-like 1 is involved in endocytic trafficking processes. It has a molecular mass of approximately 98 kDa. This protein is expressed in various tissues particularly showing higher expression levels in the epithelial cells of the gastrointestinal tract and kidney. EHBP1L1 contains multiple EH domains which help mediate protein-protein interactions necessary for cellular transport processes.
Biological function summary
EHBP1L1 facilitates the movement of vesicles by linking motor proteins to cell membranes. It participates in cellular processes such as cytoskeletal organization and membrane remodeling through its interaction with other components in a protein complex. This involvement ensures proper cellular function and maintenance of dynamic cellular structures.
Pathways
EHBP1L1 plays a role in the endocytic recycling pathway. It is essential for the internalization and recycling of membrane-bound receptors. EHBP1L1 interacts with proteins such as Rab8 and Rab11 which are small GTPases critical for membrane traffic. This protein's role helps maintain cellular homeostasis and signaling by facilitating receptor recycling.
EHBP1L1 has been linked to certain renal disorders particularly ones affecting epithelial cell function. Its association with proteins like Rab8 indicates a potential role in cystic kidney disease where vesicle trafficking pathways are disrupted. Additionally abnormal EHBP1L1 expression has connections to gastrointestinal cancers. These disorders highlight the importance of maintaining proper vesicle trafficking and membrane dynamics in cellular health.