Abcam, ab122673, Anti-ZC3H18 antibody

Size: 100µL
Rabbit Polyclonal ZC3H18 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZC3H18 aa 850-950.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZC3H18 aa 850-950. The exact immunogen used to generate this antibody is proprietary information.Q86VM9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZC3H18 also known as zinc finger CCCH-type containing 18 acts as an RNA-binding protein that plays a role in RNA processing and stability. This protein has a molecular mass of approximately 103 kDa. ZC3H18 localizes mainly in the nucleoplasm and appears in various tissues including the liver kidney and heart indicating a broad expression pattern.
Biological function summary
ZC3H18 influences transcriptional regulation and RNA maturation engaging in cellular processes such as RNA splicing. ZC3H18 forms part of a larger complex known as the PAXT connection which is involved in the degradation of RNA. Through this complex it collaborates with other proteins to ensure proper RNA turnover impacting gene expression.
Pathways
ZC3H18 operates in the RNA surveillance pathway ensuring the degradation of surplus or faulty RNAs. It plays a role in the exosome-mediated pathway and associates with proteins like RRP6 and MTR4. These pathways are part of the cell's quality control systems maintaining RNA integrity and function important for proper cellular activities.
ZC3H18 is linked with certain forms of cancer including hepatocellular carcinoma. The protein's involvement with the PAXT connection influences cancer-related pathways by modulating RNA stability. ZC3H18 through its interaction with MTR4 impacts oncogenic processes potentially serving as a target for therapeutic intervention in these disorders.