Abcam, ab124504, Anti-HAPLN2 antibody

Size: 100µg
Rabbit Polyclonal HAPLN2 antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human HAPLN2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human HAPLN2. The exact immunogen used to generate this antibody is proprietary information.Q9GZV7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HAPLN2 also known as hyaluronan and proteoglycan link protein 2 is a component of the extracellular matrix involved in stabilizing the structure of cartilage and other tissues. It has a molecular mass of approximately 41 kDa. Researchers have found HAPLN2 expression in the brain particularly in regions like the synaptic sites. It plays a part in maintaining the integrity of the perineuronal net a specialized extracellular matrix structure surrounding neurons.
Biological function summary
HAPLN2 maintains the architecture of the extracellular matrix by binding to hyaluronan and proteoglycans. This binding enhances tissue resilience and elasticity essential for normal brain function. HAPLN2 does not work alone; it forms a complex with other matrix molecules like aggrecan contributing to the matrix's stability and biological activity. This complex formation is vital for preserving tissue homeostasis and supporting cellular interactions.
Pathways
HAPLN2 contributes to extracellular matrix organization and neural development pathways. It interacts closely with proteins such as tenascin-R which play roles in guiding neural cell adhesion and migration. These pathways ensure proper neuron connectivity and repair mechanisms in the central nervous system facilitating normal development and plasticity.
HAPLN2's dysregulation connects to conditions like schizophrenia and glioblastoma. In schizophrenia altered HAPLN2 expression affects the structural properties of the perineuronal nets impacting synaptic stability and signaling. Researchers also note its connections with matrix metalloproteinases in glioblastoma as these enzymes can degrade HAPLN2 influencing tumor invasion and progression through the remodeling of the extracellular matrix.