Abcam, ab124669, Anti-ARTS1/ERAP1 antibody [EPR6069]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ARTS1/ERAP1 antibody. Suitable for IHC-P, WB and reacts with Human, Rat, Mouse samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR6069,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:The mouse and rat recommendation is based on the WB results. We do not guarantee IHC-P for mouse and rat.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Shipping conditions update: ambient shipping
This product will be delivered at ambient temperature instead of chilled – this is by design. Extensive stability testing confirmed that our products are suitable for shipment under ambient conditions and maintain expected quality.
Why the change?
It’s part of our commitment to more sustainable packaging solutions, with ambient deliveries using eco-friendly materials such as recyclable cardboard instead of polystyrene.
What you need to know
Ambient shipments come clearly marked on the delivery note.
No ice will be included in ambient shipments, but mixed orders (ambient and cold-chain items) will still arrive with ice packs to protect temperature-sensitive products.
Warranty coverage remains fully valid, aligned with our validated shipping method.
Please store the product as per the datasheet instructions upon receipt.
Find out more -
https://www.abcam.com/en-us/support/shipping-storage-support/ambient-shipping

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Conditional Ambient, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ARTS1 also known as ERAP1 (Endoplasmic Reticulum Aminopeptidase 1) is an aminopeptidase enzyme with a molecular mass of about 110 kDa. This protein is located in the endoplasmic reticulum and plays a significant mechanical role in trimming peptides for presentation by MHC class I molecules. Its expression is highly detectable in cells with robust antigen-presenting capabilities such as dendritic cells and macrophages. Additionally ARTS1/ERAP1 exists in other tissues where immune surveillance is essential.
Biological function summary
The function of ARTS1/ERAP1 involves the processing of proteolytic fragments preparing them for optimal binding to MHC class I molecules. This enzyme participates in a complex alongside ERAP2 another aminopeptidase working cooperatively to adjust peptide lengths to the correct size necessary for MHC class I presentation. Through this role ARTS1/ERAP1 influences the immune system's ability to detect and respond to infected or neoplastic cells by ensuring that antigenic peptides are properly presented.
Pathways
ARTS1/ERAP1 is a critical component of the antigen processing and presentation pathway. This pathway is essential for the presentation of endogenous antigens to cytotoxic T lymphocytes therefore playing a role in adaptive immunity. Related proteins include MHC class I molecules which present the processed peptides and TAP (Transporter associated with Antigen Processing) which transports peptides into the endoplasmic reticulum for further trimming by ARTS1/ERAP1.
Research links ARTS1/ERAP1 to ankylosing spondylitis and other autoimmune diseases. Variations in the ERAP1 gene may affect peptide trimming efficiency altering the peptide repertoire presented by MHC class I molecules and influencing autoimmune activation. The link to another protein HLA-B27 is notable in ankylosing spondylitis as this MHC class I allele frequently associates with the disease highlighting a complex interaction between ARTS1/ERAP1 enzymatic function and autoimmune susceptibility.