Abcam, ab124874, Anti-CPN1 antibody [EPR6229]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal CPN1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR6229,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Carboxypeptidase N also known as CPN or arginine carboxypeptidase is a metallo-protease enzyme with a mass of approximately 280 kDa. It exists as a tetrameric complex composed of two heavy and two light subunits. CPN1 shows expression in plasma and certain tissues like the liver influencing its functional enzyme activity. CPN1 cleaves basic amino acids like lysine and arginine from the C-terminal of peptides impacting several protein activation and inactivation processes.
Biological function summary
Carboxypeptidase N influences various physiological and pathological processes. It functions as part of a plasma-associated complex modulating peptides and proteins post-translationally. CPN1 activity regulates wound healing peptide hormone regulation and modulation of inflammatory response. The enzyme's activity influences the balance of active peptides thereby impacting downstream signaling and cellular responses.
Pathways
Carboxypeptidase N plays significant roles in the complement and kinin-kallikrein systems. In the complement system it deactivates anaphylatoxins like C3a and C5a modulating immune responses. Its ability to cleave kinins highlights its participation in the kallikrein-kinin pathway where it interacts with proteins like bradykinin influencing processes like blood pressure regulation and pain sensation.
Mutations or dysregulation of carboxypeptidase N have links with hereditary angioedema and neuropathological disorders. Hereditary angioedema stems from CPN1's role in metabolizing bradykinin which if not regulated leads to excessive edema. Connections between CPN1 and disorders like schistosomiasis exist involving its interaction with complement proteins C3a and C5a implicating this enzyme in immune response misregulation.