Abcam, ab124885, Anti-FLCN antibody [EPNCIR147]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal FLCN antibody. Suitable for WB and reacts with Human samples. Cited in 7 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPNCIR147,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
This antibody was developed as part of a collaboration between the National Cancer Institute's Center for Cancer Research and the lab of Marston Linehan.
View antibodies from NCI Center for Cancer Research Collaboration
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Folliculin (FLCN) protein also known by its gene name BHD serves as a tumor suppressor and has significant roles in cellular processes. FLCN comprises 579 amino acids resulting in a molecular weight of approximately 64 kDa. It expresses in various tissues notably in the skin kidney and lung. FLCN interacts with several proteins and serves essential roles in maintaining cell stability.
Biological function summary
FLCN plays a role in energy and nutrient sensing within cells. It forms part of a complex with FNIP1 and FNIP2 proteins which helps regulate cellular growth and metabolism. This complex acts as a hub for integrating various signaling pathways influencing how cells respond to changing metabolic states.
Pathways
Research connects FLCN to the mTOR signaling pathway and AMP-activated protein kinase (AMPK) pathway which are critical for cellular metabolism and energy homeostasis. The interaction between FLCN and the mTOR pathway facilitates control over cell growth and proliferation by sensing cellular energy levels. Moreover FLCN associates with pathways that include proteins like TSC1 and TSC2 which also contribute to the regulation of these pathways.
FLCN mutations link to Birt-Hogg-Dubé syndrome a genetic disorder causing skin lung and kidney anomalies. Its dysfunction also associates with certain types of kidney cancer where FLCN's tumor suppressor role becomes evident. Altered interactions between FLCN and other proteins such as AMPK can contribute to disease progression highlighting FLCN's importance in medical research concerning cancer and genetic disorders.