Abcam, ab126133, Anti-ZNHIT2 antibody

Size: 50µL
Rabbit Polyclonal ZNHIT2 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZNHIT2 aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZNHIT2 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q9UHR6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNHIT2 also known as Zinc Finger HIT-Type Containing 2 is a protein that plays a role in transcription regulation by modulating the activity of other proteins. With a molecular mass of approximately 31 kDa this protein is characterized by the presence of a zinc-finger HIT domain. ZNHIT2 is expressed in various tissues including the brain testis and heart indicating its involvement in diverse physiological processes. Its expression pattern suggests a significant role in cellular activities affecting many tissue types.
Biological function summary
ZNHIT2 participates in the assembly and function of essential ribonucleoprotein complexes. It acts as a facilitator in the modification of these complexes ensuring proper ribosome maturation and function. ZNHIT2 is part of larger multi-subunit complexes that include proteins from the U3 snoRNP complex impacting the processing of precursor rRNA. Its presence in these complexes highlights its involvement in maintaining the efficiency of cellular protein synthesis mechanisms.
Pathways
ZNHIT2 plays a role in the ribosome biogenesis pathway. It directly interacts with other proteins like NOLC1 and BOP1 which are important for the production of functional ribosomes. These interactions ensure the proper progression and regulation of ribosomal assembly and function making ZNHIT2 an important player in the protein synthesis pathway. By coordinating with these proteins ZNHIT2 helps maintain cellular homeostasis and protein production.
Alterations in ZNHIT2 expression have been implicated in neurodegenerative diseases and certain cancers. ZNHIT2's interaction with proteins such as NOP56 and DDX21 links it to disorders like spinocerebellar ataxias (SCAs) where ribosome biogenesis is disrupted. Additionally in some cancers ZNHIT2 expression levels may affect tumor progression due to its influence on cellular growth mechanisms. Understanding how ZNHIT2 functions in these contexts can provide insights into potential therapeutic strategies.