Abcam, ab126340, Anti-FAM173A antibody

Size: 100µL
Rabbit Polyclonal FAM173A antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ANTKMT aa 100 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ANTKMT aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9BQD7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FAM173A also known as Family with Sequence Similarity 173 Member A is a protein with a mass of approximately 33 kDa. It works mechanically within the cell and is thought to have a role in mitochondrial dynamics possibly influencing mitochondrial partitioning. FAM173A is widely expressed in various tissues but high expression levels have been reported in the brain and muscle tissues. Its subcellular localization suggests a mitochondrial association which might indicate specific functions linked to energy production or regulation within the mitochondria.
Biological function summary
The precise role of FAM173A is still not entirely understood yet it appears to participate in mitochondrial maintenance and possibly cellular energy homeostasis. FAM173A might function as part of larger protein complexes potentially impacting the regulation of mitochondrial genome integrity or biogenesis. Its involvement in these processes highlights the importance of FAM173A in maintaining cellular functions and energy balance contributing to the proper physiological functions of tissues with high metabolic demands.
Pathways
FAM173A operates within mitochondrial-related pathways that are critical for energy metabolism and maintaining cellular homeostasis. It might interact with components of the oxidative phosphorylation pathway though specific pathway associations require further elucidation. FAM173A possibly intersects with proteins like MFN2 and OPA1 which are known to regulate mitochondrial fusion and fission processes. Understanding how these interactions affect cellular energy balance and mitochondrial morphology is essential for full comprehension of FAM173A's role within these pathways.
Research indicates that abnormal FAM173A function might be linked to neurodegenerative diseases and muscular disorders. Altered expression or mutations in FAM173A have been studied in diseases such as Alzheimer's and muscular dystrophies. FAM173A's connection to these diseases may involve interactions with proteins like APP in Alzheimer's disease and dystrophin in muscular disorders. These associations highlight the potential of FAM173A as a target for therapeutic strategies aiming to mitigate the effects of these conditions by restoring proper mitochondrial function.