Abcam, ab126354, Anti-SPATA5L1 antibody

Size: 100µL
Rabbit Polyclonal SPATA5L1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human AFG2B aa 500-650.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human AFG2B aa 500-650. The exact immunogen used to generate this antibody is proprietary information.Q9BVQ7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SPATA5L1 also known as Spermatogenesis-Associated 5-Like 1 is a protein with a molecular mass of approximately 69 kDa. It plays a role in the cellular mechanisms that regulate protein interactions and stability. SPATA5L1 expresses in a wide range of tissues with higher concentrations observed in reproductive tissues suggesting a potential role in reproductive biology. Its expression pattern indicates involvement in specialized cellular processes that require precise regulation.
Biological function summary
SPATA5L1 participates in processes that involve cellular growth and differentiation. It is not a member of a specific protein complex but interacts with multiple signaling proteins to execute its functions. SPATA5L1 supports the maintenance of cellular homeostasis by ensuring proper functioning of molecular pathways. Its role becomes essential in cells requiring rapid division and growth where it impacts cellular dynamics and function.
Pathways
SPATA5L1 interacts with regulatory networks involved in cell cycle control and RNA processing. In particular it associates with the MAPK signaling pathway which plays a role in transmitting signals from cell surface receptors to the DNA in the nucleus. This pathway connects SPATA5L1 with proteins such as MEK and ERK which modulate cellular responses to external stimuli. By operating within these pathways SPATA5L1 affects processes essential for cellular adaptation and survival.
SPATA5L1 shows associations with certain reproductive disorders. Its dysregulation is linked to impaired spermatogenesis potentially leading to infertility. Additionally abnormal expression levels may have implications in cancer biology as SPATA5L1 interacts with proteins like p53 an important regulator in tumor suppression pathways. These associations suggest SPATA5L1 as a relevant target for understanding and potentially managing related disease mechanisms.