Abcam, ab126792, Anti-DEF6 antibody [EPR7492]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal DEF6 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7492,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DEF6 also known as Differentially Expressed in FDCP 6 or SWAP-70 like adapter of T cells is a protein with a molecular mass of approximately 74 kDa. It functions as a guanine nucleotide exchange factor (GEF) and has a critical role in regulating cytoskeletal dynamics. DEF6 is predominantly expressed in hematopoietic cells specifically in T and B lymphocytes where it facilitates various cell signaling pathways. Its expression is firmly noted in immune-related tissues contributing to its significance in immune response modulation.
Biological function summary
DEF6 enhances actin cytoskeleton remodeling by activating Rho GTPases. It associates with other proteins to form complexes that modulate cell mobility and immune cell activation. Through its GEF activity DEF6 influences cell shape movement and signaling especially within immune cells. It plays a part in adaptive immune responses by assisting the rearrangement of actin filaments necessary for effective immune cell function.
Pathways
DEF6 integrates into signaling pathways like the T-cell receptor (TCR) signaling and B-cell receptor (BCR) signaling. Within these pathways DEF6 interacts with adaptor proteins such as LAT and SLP-76 important for downstream signaling events. Its role in these pathways ensures proper communication and immune system function as it helps transmit signals from the cell surface to the nucleus therefore influencing lymphocyte activation and differentiation.
DEF6 has connections with autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). DEF6's involvement in these conditions links to its regulatory role in immune cell signaling which can affect autoantibody production and inflammation. Studies show that DEF6 might interact with proteins such as STAT4 and IRF5 which are also associated with autoimmune disease susceptibility providing insight into its therapeutic potential in these disorders.