Abcam, ab127196, Anti-ZNF31 antibody

Size: 50µL
Rabbit Polyclonal ZNF31 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZSCAN20 aa 300-550.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZSCAN20 aa 300-550. The exact immunogen used to generate this antibody is proprietary information.P17040

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF31 also known as zinc finger protein 31 functions mechanically as a gene transcription regulator. It belongs to a family of proteins containing zinc finger motifs key to binding DNA and influencing gene expression. ZNF31 has a molecular mass of approximately 198 kDa and can be found predominantly in the nucleus of cells. It is expressed in various tissues including the brain and liver where it likely participates in essential regulatory roles.
Biological function summary
This target plays a significant role in controlling gene expression by binding specific DNA sequences. ZNF31 acts as a transcription factor; it can either activate or repress the expression of target genes. Evidence suggests that ZNF31 is part of a transcriptional complex that may involve other zinc finger proteins. These interactions enable ZNF31 to modulate cellular processes like proliferation and differentiation highlighting its regulatory capacity in cellular biology.
Pathways
Researchers have identified ZNF31 as a contributor to processes within the cell cycle and apoptosis pathways. In the cell cycle ZNF31 interacts with other proteins to influence cell proliferation and division. It has a relationship with p53 an important protein that regulates the cell cycle and promotes apoptosis if DNA damage is detected. The regulation of these pathways highlights the involvement of ZNF31 in maintaining normal cellular function and preventing abnormal cell growth.
ZNF31 has been associated with various types of cancer where dysregulation might result in aberrant cell proliferation. The interaction of ZNF31 with oncogenes or tumor suppressor proteins like p53 suggests its role in either promoting or inhibiting tumor growth depending on the context. Additionally there is ongoing research studying its involvement in neurological disorders given its expression in the brain. These potential links offer insights into how ZNF31 dysfunction may contribute to the development of these diseases.