Abcam, ab128094, Anti-PGM3 antibody [OTI1A11]

Size: 100µL
Mouse Monoclonal PGM3 antibody. Suitable for WB, IHC-P, Flow Cyt (Intra) and reacts with Mouse, African green monkey, Transfected cell lysate - Human, Human, Transfected cell line - Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PGM3.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI1A11,
Isotype:IgG1,
Carrier free:No,
Reacts with:Mouse, Human, African green monkey,
Applications:IHC-P, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human PGM3.O95394

Product details:
The clone number has been updated from 1A11 to OTI1A11, both clone numbers name the same antibody clone.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant by affinity chromatography, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Phosphoglucomutase 3 (PGM3) is a critical enzyme involved in carbohydrate metabolism. It catalyzes the conversion of N-acetylglucosamine-6-phosphate to N-acetylglucosamine-1-phosphate an important step in nucleotide sugar metabolism. PGM3 is also known as AGM1. The molecular weight of PGM3 is approximately 61 kDa. Expression of PGM3 is widespread with significant levels found in liver pancreas and brain tissue indicating its importance in energy metabolism in these organs.
Biological function summary
The role of PGM3 extends beyond simple carbohydrate conversion. PGM3 participates in the synthesis of glycosylation substrates essential for glycan production on proteins and lipids. It functions as a single enzyme not part of a larger complex. Glycosylation is critical for protein folding stability and cell-cell communication and defects in this process can affect numerous cellular activities.
Pathways
PGM3 integrates into the nucleotide sugar metabolism pathway important for glycosylation. It also intersects with the hexosamine biosynthetic pathway. Through these pathways PGM3 directly connects with proteins involved in cellular growth and differentiation such as OGT (O-linked N-acetylglucosamine transferase) which modifies nuclear and cytosolic proteins through O-GlcNAcylation.
PGM3 mutations link to immune system disorders notably immunodeficiency. Genetic variants of PGM3 can result in aberrant glycosylation leading to immune dysfunction and increased susceptibility to infections. Moreover defects in PGM3 are associated with skeletal abnormalities and developmental delays potentially involving interactions with proteins such as N-glycosylated cell surface receptors.