Abcam, ab128911, Anti-ACAA2 antibody [EPR6733]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ACAA2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR6733,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ACAA2 also known as acetyl-CoA acyltransferase 2 or 3-ketoacyl-CoA thiolase plays an important role in the mechanical process of fatty acid oxidation. It functions in the mitochondria where it catalyzes the final step of the beta-oxidation pathway facilitating the conversion of acetoacetyl-CoA to two molecules of acetyl-CoA. This protein has a known mass of approximately 43 kDa. ACAA2 is expressed in tissues with high energy demands such as the liver heart and muscle highlighting its significance in energy metabolism.
Biological function summary
The enzyme catalyzes reactions in energy metabolism by breaking down fatty acids to generate energy. ACAA2 functions as part of the complex mitochondrial fatty acid beta-oxidation machinery. This process supports energy production particularly under conditions of carbohydrate depletion. The production of acetyl-CoA by ACAA2 is important for the TCA cycle through which cells generate ATP the primary energy carrier.
Pathways
Acetyl-CoA acyltransferase 2 plays significant roles in both the fatty acid beta-oxidation and ketogenesis pathways. In the beta-oxidation pathway it works together with other enzymes like CPT1A and HADHB to efficiently break down fatty acids. In ketogenesis acetyl-CoA units produced by ACAA2 are directed towards the formation of ketone bodies which serve as an alternative energy source for the brain and muscles during fasting or prolonged exercise.
ACAA2 has connections to metabolic disorders particularly fatty acid oxidation disorders and diabetes. Deficiency in ACAA2 activity can result in accumulation and impaired degradation of fatty acids leading to metabolic imbalances. This enzyme also interacts with related proteins such as ACADM in the context of these metabolic diseases. Disruptions in ACAA2 function can face links to mitochondrial dysfunctions that contribute to diabetes due to its role in energy production and regulation.