Abcam, ab128925, Anti-GPCR GPR63 antibody [EPR7447]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal GPCR GPR63 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7447,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
G protein-coupled receptor 63 (GPCR GPR63) also known simply as GPR63 is a member of the GPCR family. GPCRs are integral membrane proteins involved in transmitting signals from the outside to the inside of cells. GPR63 has a molecular mass of approximately 45 kDa and is expressed in the human brain particularly in areas such as the thalamus and putamen. Despite the identification of GPR63 scientists have not fully clarified its ligands and specific endogenous activators which remains a topic of ongoing research.
Biological function summary
GPR63 mediates cellular responses essential for brain function. While not part of a larger multi-protein complex it is suspected to influence neuronal signaling pathways. These pathways often affect processes such as neuroinflammation and neurotransmission. The specific biological roles remain to be fully determined but studies indicate GPR63's involvement in maintaining neural communication and possibly impacting synaptic plasticity.
Pathways
We find that GPR63 engages in signaling routes such as the G protein-coupled receptor signaling pathway and potentially influences the cyclic AMP (cAMP) signaling pathway as well. These pathways play important roles in cellular responses and neurological functions. Related proteins in these pathways could include other GPCRs and proteins like adenylate cyclase which can interact with receptors like GPR63 fitting into broader signaling networks in the brain.
GPR63 has been linked to neurological conditions including schizophrenia and depression. Studies suggest that aberrations in GPR63 signaling may influence these conditions by affecting neurotransmitter balance and brain signaling integrity. This target's connection to proteins involved in these disorders such as dopamine receptors highlights its potential importance in understanding and addressing mental health disorders. Further research may uncover additional roles and therapeutic targets related to GPR63.