Abcam, ab129070, Anti-PTP1B + TCPTP antibody [EPR6712]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PTP1B antibody. Suitable for IP, WB, Flow Cyt (Intra) and reacts with Human, Mouse, Recombinant full length protein - Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR6712,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:Flow Cyt (Intra), IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PTP1B also known as protein tyrosine phosphatase non-receptor type 1 mechanically functions as an important regulator of signaling pathways by removing phosphate groups from tyrosine residues on target proteins. It has an approximate mass of 50 kDa and is widely expressed in various tissues including the liver muscle and both central and peripheral nervous systems. TCPTP another name for this protein has similar enzymatic properties and serves overlapping and distinct functions in cellular regulation.
Biological function summary
Protein tyrosine phosphatase 1B (PTP1B) plays a critical role in controlling cell growth differentiation and metabolism. It influences the insulin signaling pathway affecting glucose homeostasis and energy utilization. PTP1B also engages in immune cell signaling and modulation of inflammatory responses. While typically studied independently this phosphatase can also form part of larger molecular complexes that impact broader signaling environments.
Pathways
Protein tyrosine phosphatase 1B acts as a central node in the insulin and leptin signaling pathways. These pathways significantly influence metabolic processes and energy balance with PTP1B modulating key interactions with insulin receptors and leptin receptors. It closely interacts with proteins such as IRS1 and IRS2 which play substantial roles in transmitting signals downstream of insulin action impacting cellular uptake of glucose and lipid metabolism.
Improper regulation of PTP1B links to type 2 diabetes and obesity due to its involvement in insulin resistance and energy imbalance. Altered PTP1B activity affects insulin receptor function contributing to the pathophysiology of these metabolic disorders. Additionally in relation to obesity PTP1B modulates leptin receptor signaling an important aspect in energy expenditure and weight regulation. These connections make it a target for potential therapeutic interventions focused on metabolic diseases.