Abcam, ab129444, Anti-MTG16 antibody

Size: 100µg
Rabbit Polyclonal MTG16 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human CBFA2T3 aa 600 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CBFA2T3 aa 600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O75081

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MTG16 also known as myeloid translocation gene 16 is a transcriptional corepressor weighing approximately 145 kDa. It collaborates with other transcription factors to regulate gene expression during hematopoiesis. You can find MTG16 predominantly expressed in hematopoietic cells particularly within bone marrow. It interacts with several chromatin-remodeling complexes influencing the transcriptional machinery intricately.
Biological function summary
MTG16 modulates blood cell development and differentiation processes. As part of a transcriptional repressor complex MTG16 interacts with histone deacetylases and various other corepressors. This interaction suppresses target gene transcription maintaining precise control over cell lineage commitment. This regulatory role is essential in hematopoiesis where precise control of gene expression determines cell fate.
Pathways
The role of MTG16 is significant in the Notch signaling and Wnt signaling pathways. In the Notch pathway MTG16 modulates the expression of genes through interaction with the Groucho family of corepressors impacting cell fate decisions. It also interacts with β-catenin in the Wnt signaling pathway which is important for regulating embryonic development and cellular proliferation. These pathways illustrate the central role of MTG16 in maintaining cellular homeostasis and development.
MTG16 has connections to leukemia and myelodysplastic syndromes. Altered MTG16 expression is frequently observed in acute myeloid leukemia (AML) where it interacts with AML1-ETO a fusion protein resulting from chromosomal translocation. The dysfunction of this interaction may disrupt normal hematopoietic differentiation contributing to leukemogenesis. Additionally aberrations in MTG16 expression levels have implications in myelodysplastic syndromes which are characterized by ineffective hematopoiesis.