Abcam, ab129459, Anti-KLF12 antibody

Size: 100µg
Rabbit Polyclonal KLF12 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 13 publications. Immunogen corresponding to Synthetic Peptide within Human KLF12 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human KLF12 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q9Y4X4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab129459 is affinity purified using an epitope specific to KLF12 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KLF12 also known as Krüppel-like factor 12 is a transcription factor with a mass of approximately 37 kDa. This protein is expressed in diverse tissues including the liver heart and brain. KLF12 modulates gene expression by binding to specific DNA sequences with its zinc finger domains. The factor plays an important role in transcription regulation by interacting with promoter regions of target genes.
Biological function summary
KLF12 influences cell differentiation proliferation and apoptosis. It operates as part of transcriptional complexes often interacting with co-regulators such as histone deacetylases. The protein controls the expression of critical genes involved in cellular growth and maintenance exerting broad impacts on cellular phenotype. KLF12's interaction with co-repressors alters chromatin structure influencing transcriptional landscapes.
Pathways
KLF12 regulates the Wnt signaling pathway which is significant for controlling cell fate and migration. KLF12 interacts with components like beta-catenin altering the pathway's output and affecting cellular responses to developmental signals. Additionally KLF12 is linked to the TGF-beta signaling pathway influencing related proteins and impacting cellular processes such as proliferation and differentiation.
KLF12 shows strong associations with cancer particularly colorectal cancer. It interacts with proteins like E-cadherin affecting the epithelial-to-mesenchymal transition an important step in cancer metastasis. Furthermore KLF12 also connects to neurodegenerative disorders influencing factors linked to neural integrity and function underlining its potential role in pathological processes.