Abcam, ab129875, Anti-ZAR1 antibody

Size: 100µg
Rabbit Polyclonal ZAR1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab129875 is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen., Storage buffer-pH: 7 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZAR1 also known as Zygote Arrest 1 is a protein involved in early embryonic development. It has a mass of approximately 42 kDa and is selectively expressed in oocytes and early embryos. ZAR1 plays an important role in regulating processes during oocyte maturation and embryogenesis. Its expression is mainly restricted to the female reproductive system particularly in the ovaries during developmental stages essential for fertilization and zygote formation.
Biological function summary
The activity of ZAR1 centers around its ability to control the cell cycle and maintain genomic stability. It acts as part of a regulatory complex that interacts with other proteins to ensure successful zygote development. ZAR1's role involves safeguarding the early stages of fertilization by stabilizing maternal mRNA and assisting in the transition from maternal to zygotic control. This protein is fundamental in the early phases of embryo development guiding processes that are instrumental for life continuation.
Pathways
ZAR1 is important in mechanisms such as the maternal-zygotic transition and cell cycle regulation pathways. ZAR1 collaborates with other proteins like YBX2 and DDX6 to facilitate these pathways ensuring a smooth transition of control from maternal to embryonic genome. Additionally it is involved in pathways that coordinate checkpoints during cell division illustrating its vital roles within highly regulated molecular frameworks essential for embryogenesis.
ZAR1 has associations with infertility and other reproductive issues. Abnormalities in ZAR1 function may disrupt normal embryo development leading to infertility or defective embryonic cell cycles. The protein interacts with other development-related proteins providing potential therapeutic targets for infertility treatments. Additionally ZAR1's dysfunction could contribute to fragmentary embryonic development increasing the risk for early pregnancy loss connecting it to disorders requiring further reproductive health research.