Abcam, ab129984, Anti-OR5P2 antibody

Size: 100µg
Rabbit Polyclonal OR5P2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human OR5P2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human OR5P2. The exact immunogen used to generate this antibody is proprietary information.Q8WZ92

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen., Storage buffer-pH: 7Preservative: 0.02% Sodium azideConstituents: 50% Glycerol (glycerin, glycerine), 44% N-(3-methylbutanoyl)-L-valyl-N-{4-[(2-{[1-(2-carboxy-1-hydroxyethyl)-3-methylbutyl]amino}-1-methyl-2-oxoethyl)amino]-2-hydroxy-1-isobutyl-4-oxobutyl}-L-valinamide, 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
OR5P2 also known as Olfactory Receptor 5P2 is a protein involved in the detection of odorants in the olfactory system. This protein belongs to the olfactory receptor family which is characterized by its seven transmembrane domain structure typical of G-protein-coupled receptors (GPCRs). The mass of OR5P2 is approximately 35 kDa. Expression of OR5P2 mainly occurs in the olfactory epithelium within the nasal cavity where it plays a direct role in binding odorant molecules and initiating a signal transduction pathway.
Biological function summary
OR5P2 helps organisms perceive and respond to environmental chemical cues. It operates as part of a larger receptor complex working together with other olfactory receptors to enable the sense of smell. This receptor recognizes specific odorant molecules and upon binding it activates a signaling cascade that ultimately results in a neuronal response. The specificity and diversity of olfactory receptors including OR5P2 allow organisms to detect a wide array of odorant molecules with high sensitivity.
Pathways
Olfactory receptors like OR5P2 contribute to the olfactory transduction pathway an important sensory signaling pathway that transforms chemical signals into electrical responses in the brain. Important components of this pathway include the G protein Golf which gets activated upon receptor-ligand binding and adenylate cyclase which increases cyclic AMP levels leading to neuronal depolarization. OR5P2's role in this cascade is akin to other olfactory receptors such as OR1A1 which also participate in translating chemical signals into perception.
Alterations in the function of OR5P2 have implications for anosmia or the loss of the sense of smell though direct associations are not as well-studied as in other olfactory genes. Research has also explored the potential connection of olfactory receptors to neurodegenerative conditions like Alzheimer's disease because of the early symptom of olfactory dysfunction. Proteins such as amyloid-beta which is linked to neurodegeneration may indirectly interact with olfactory pathways to affect sensory function.