Abcam, ab130417, Anti-WDR21A antibody

Size: 100µL
Rabbit Polyclonal WDR21A antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DCAF4 aa 50-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human DCAF4 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.Q8WV16

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
WDR21A also known as STRAP or Mak10 acts as an important component of cellular processes such as gene expression and signal transduction. Mechanically the WDR21A protein features a series of WD40 repeats which facilitate protein-protein interactions. Its molecular weight stands around 39 kDa. Researchers identify an expression of WDR21A across various tissues with observable levels in the liver lung and kidney highlighting its essential presence in the human body.
Biological function summary
Associated with cellular machinery WDR21A serves as a co-chaperone in complex regulatory mechanisms. It functions within the prefoldin complex contributing to the stabilization of nascent polypeptides and assisting with proper protein folding. This participation plays a direct role in maintaining cellular homeostasis and efficiency by preventing misfolded protein aggregation. Dysregulation within these processes can lead to cellular stress and malfunctioning pathways emphasizing the role of WDR21A in maintaining cellular order.
Pathways
WDR21A plays a role in pathways like the TGF-beta signaling and mTOR pathways which are critical in regulating cell growth proliferation and differentiation. Within these pathways WDR21A interacts with proteins such as Smad4 and Raptor. These interactions showcase the integrated role of WDR21A in facilitating important cellular responses to external and internal cues thereby influencing various cellular outcomes and states.
Alterations in WDR21A expression have been linked to cancer particularly hepatocellular carcinoma and its involvement in neurodegenerative disorders such as Huntington's disease. The connection to cancer involves interactions with proteins like Smad4 impacting cell cycle regulation and apoptosis. In neurodegeneration WDR21A's relationship with Huntington protein highlights its impact on neuroprotective pathways emphasizing the importance of its regulation for preventing disease progression.