Abcam, ab131159, Anti-Nicalin antibody [EPR8528]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Nicalin antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8528,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:This antibody is not suitable for testing tissue samples.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Nicalin also known as NOMO1 is a protein involved in the Notch signaling pathway and has an approximate molecular mass of 70 kDa. This protein localizes predominantly in the endoplasmic reticulum. Nicalin expresses across multiple tissue types but shows higher levels in neural tissues. It interacts with Nomo1 and other proteins to form a multi-protein complex that modulates signaling functions.
Biological function summary
Nicalin acts as a regulator of Notch signaling an essential pathway for cell differentiation and development. It is a part of Nicalin-Nomo1 complex playing a significant role in modulating protein interactions. This complex contributes substantially to modifying cell fate decisions especially in the nervous system. Nicalin's presence in this complex highlights its importance in fine-tuning signaling mechanisms.
Pathways
Nicalin's function strongly influences Notch and Wnt signaling pathways. These pathways are important for processes such as cell proliferation and apoptosis. In the Notch pathway Nicalin forms interactions with the Presenilin protein influencing the maturation of Notch receptor proteins. This interaction affects cellular communication highlighting Nicalin's integrative role within signaling networks.
Nicalin shows a connection to neurodegenerative diseases like Alzheimer's Disease where its interaction with Presenilin is significant. The protein also relates to developmental disorders influencing nervous system development due to its role in the Notch signaling pathway. Nicalin's regulation within these pathways can impact disease progression and severity indicating its potential as a therapeutic target.