Abcam, ab131257, Anti-MKK6 (phospho S207) antibody

Size: 100µg
Rabbit Polyclonal MP2K6 phospho S207 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MAP2K6 phospho S207 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human MAP2K6 phospho S207 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P52564

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antibody was purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatography using non-phosphopeptide., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MKK6 also known as MAP2K6 functions as a dual-specificity kinase within cellular signaling processes. It belongs to the MAP kinase kinase (MAP2K) family and specifically activates p38 MAP kinase by phosphorylation. This protein weighs approximately 38 kDa and is expressed in various tissues with higher levels often found in the brain heart and skeletal muscle. MKK6 plays a significant role in transmitting signals that regulate cellular responses to stress and inflammation.
Biological function summary
This protein modulates important cellular mechanisms by acting as an important component of the p38 MAPK signaling cascade. It interacts with other kinases to form signaling complexes that mediate responses like cell growth division and apoptosis. MKK6 becomes activated in response to environmental stressors and cytokines triggering a phosphorylation cascade that concludes with the activation of p38 MAPK which then enters the nucleus to influence gene expression.
Pathways
MKK6 integrates into the MAPK signaling pathway particularly in stress response and inflammatory signaling pathways. The protein activates p38 MAPK an important player in these pathways and associates with other proteins such as MKK3 and MKK4 to regulate diverse cellular activities. This activation is a part of well-established pathways like cytokine production and response to DNA damage offering comprehensive regulation of cellular homeostasis.
MKK6 involvement links to inflammatory conditions and stress-related pathologies. It has been implicated in diseases like rheumatoid arthritis where its activity relates to increased inflammatory responses and also in cancer contributing to tumor growth and survival via p38 MAPK activation. Through these conditions MKK6 connects closely with other proteins within the MAPK pathway including p38 MAPK which plays a role in the alteration of cellular proliferation and apoptosis often observed in pathological states.