Abcam, ab131928, Recombinant Human CAPON/NOS1AP protein

Size: 10µg
Recombinant Human CAPON/NOS1AP protein is a Human Full Length protein, in the 1 to 506 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:SDS-PAGE, ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:O75052,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Product details:
This product was previously labelled as CAPON.

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CAPON also known as NOS1AP (nitric oxide synthase 1 adaptor protein) is an adaptor protein with a molecular weight of about 55 kDa. This protein interacts primarily with neuronal nitric oxide synthase (nNOS) modulating its activity. CAPON is expressed in the brain particularly in regions like the hippocampus and cerebral cortex where it plays roles in neuronal signaling. Its involvement in the brain implies its importance in neural functions and cognitive processes.
Biological function summary
CAPON influences signal transduction processes involving nitric oxide. As part of a molecular complex it binds with nNOS which leads to the modulation of nitric oxide production. This regulation impacts synaptic plasticity and neurotransmission hence affecting learning and memory. By interacting with other signaling proteins CAPON can affect the cellular response to various stimuli making it a significant player in neuronal communication.
Pathways
CAPON’s function fits into the nitric oxide signaling pathway which is important for neuron communication and vasodilation processes. It associates with the ERK/MAPK pathway which plays a role in cognition and neural development. Through nitric oxide modulation it influences other proteins such as PSD95 a postsynaptic density protein which impacts synaptic organization and function. This involvement showcases its role in maintaining neuronal integrity and function within these pathways.
CAPON has ties to neurologic and psychiatric conditions specifically schizophrenia and bipolar disorder. Alterations in its interaction with nNOS have been linked to the pathophysiology of these conditions. Additionally CAPON's connection with proteins like PSD95 suggests it may impact synaptic organization which can be disrupted in such mental health disorders. Understanding CAPON’s role could contribute to therapeutic approaches in these diseases.