Abcam, ab132175, Recombinant Human CAB3 protein

Size: 10µg
Recombinant Human CAB3 protein is a Human Full Length protein, in the 1 to 484 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P54284,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Product details:
This product was previously labelled as CACNB3.

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CAB3 also known as calcineurin B homologous protein 3 (CaCNB3) is a protein involved in intracellular signaling. The protein weighs approximately 22 kDa and expresses in various tissues including the heart and brain. Functionally CAB3 participates in calcium-binding and signaling processes facilitating interactions essential for cellular responses to changes in calcium levels.
Biological function summary
CAB3 plays an integral role in calcium-dependent signaling pathways. This protein functions as part of a larger calcineurin complex alongside calcineurin A. CAB3 and the complex it forms modulate the activity of several downstream targets influencing cellular processes like gene expression and cytoskeletal dynamics. In neurons CAB3 contributes to the synaptic plasticity necessary for learning and memory.
Pathways
CAB3 is an important component in calcium and NFAT signaling pathways. It directly regulates these pathways impacting gene expression and cellular development. CAB3 interacts with other proteins like calmodulin which facilitates its binding and functional actions within the pathway. Through modulation of these pathways CAB3 participates in orchestrating cellular responses to external stimuli.
Mutations or dysregulation of CAB3 relate to cardiac hypertrophy and neurodegenerative diseases such as Alzheimer’s. Misregulation of CAB3 activity can disrupt calcium homeostasis aggravating disease processes. The connection to calcineurin is significant as alterations in this relationship could influence the progression of these disorders offering potential targets for therapeutic intervention.