Abcam, ab13225, Anti-PTPRK antibody

Size: 100µg
Rabbit Polyclonal PTPRK antibody. Suitable for WB and reacts with Recombinant fragment - Human, Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PTPRK also known as receptor-type tyrosine-protein phosphatase kappa is a protein involved in dephosphorylation processes. It has a molecular weight of approximately 145 kDa. The protein functions as a dimer and is encoded by the PTPRK gene. It is widely expressed in various tissues like the skin testes and colon. PTPRK interacts with other proteins at its extracellular region influencing cell adhesion and growth.
Biological function summary
PTPRK plays a role in regulating cell signaling by removing phosphate groups from phosphotyrosine residues on proteins. This activity influences cell growth differentiation and cellular communication. As a receptor-type protein tyrosine phosphatase it acts as a mediator in cell-cell adhesion and contact inhibition of cell growth. The protein is involved in the regulation of E-cadherin-mediated adhesion suggesting its importance in cell junctions.
Pathways
PTPRK is an important component in the Hedgehog and Wnt signaling pathways. These pathways are essential for embryonic development and maintenance of adult tissue homeostasis. PTPRK interacts with the calcium-dependent cell adhesion protein E-cadherin to mediate signal transduction within these pathways. The interplay with these pathways suggests its involvement in maintaining cellular architecture and function.
PTPRK has been associated with cancer and autoimmune diseases. Dysregulation of PTPRK expression or function can contribute to the development of colorectal cancer. Moreover altered PTPRK activity is implicated in psoriasis an autoimmune skin disorder where it is linked through an association with altered E-cadherin expression. These connections highlight the role of PTPRK in disease pathology and its potential as a therapeutic target.