Abcam, ab133239, Anti-DN-7 antibody [EPR5266]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal DN-7 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR5266,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DN-7 also known as Dedicated Nucleotide 7 or DNase-7 is a protein with a molecular mass of approximately 30 kDa. It plays a role in the breakdown of nucleic acids functioning efficiently in cellular environments where DNA turnover is high. DN-7 expression occurs across various tissues with notable levels in the spleen and thymus. This expression pattern reflects its involvement in the degradation of extranuclear DNA helping to maintain cellular homeostasis.
Biological function summary
DN-7 contributes to nucleic acid metabolism where it prevents the accumulation of DNA fragments. Its enzymatic activity facilitates the clearance of excess DNA critical for avoiding autoimmune reactions. DN-7 often partners with other nucleases forming transient complexes that enhance its efficacy particularly during the cell apoptosis process. These interactions highlight its importance in maintaining genomic stability.
Pathways
DN-7 integrates into the apoptosis pathway working alongside proteins such as caspases. Through regulated DNA cleavage DN-7 supports the systematic dismantling of cellular components during apoptosis. Another pathway involving DN-7 is DNA repair where it complements proteins like PARP ensuring any nonspecific DNA damage is adequately resolved to maintain genomic integrity.
DN-7 has connections to systemic lupus erythematosus (SLE) and other autoimmune conditions. Insufficient activity of DN-7 can lead to improper DNA clearance a factor contributing to autoimmune responses. Additionally abnormal DN-7 function relates to certain cancer types where its imbalance can influence tumor proliferation. In these contexts DN-7 interacts with proteins like DNase II affecting disease progression and pathology.