Abcam, ab133560, Anti-CARD9 antibody [EPR6489]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal CARD9 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR6489,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please
contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CARD9 also known as Caspase Recruitment Domain Family Member 9 is a signaling protein that plays a critical role in immune cell function. It has a molecular mass of approximately 59 kDa. CARD9 is primarily expressed in myeloid cells including dendritic cells monocytes and macrophages. Its mechanical function involves acting as an adaptor protein in immune signaling pathways allowing it to mediate the interaction between upstream pattern recognition receptors and downstream kinases.
Biological function summary
CARD9 is instrumental in the activation of the immune system’s response to pathogens such as fungi and bacteria. It functions as part of the CARD-Bcl10-MALT1 signaling complex which triggers the activation of NF-kB a transcription factor essential for inflammatory responses. Through its role in this complex CARD9 ensures the regulation of cytokine production which is fundamental for effective immune responses. CARD9's activity supports the defense against pathogenic infections by facilitating communication in immune signaling.
Pathways
CARD9 is involved in critical immune response pathways including the C-type lectin receptor (CLR) pathway. This pathway is essential in recognizing fungal pathogens and initiating immune responses. CARD9 interacts with proteins like Syk and Bcl10 in the CLR pathway to propagate immune signaling. CARD9's role in these pathways highlights its significance in regulating immune activities and maintaining homeostasis through signaling cascades.
CARD9 deficiency can result in impaired immune responses leading to increased susceptibility to fungal infections such as candidiasis. The protein plays an important role in maintaining appropriate immune functions to prevent such conditions. Furthermore dysfunction in CARD9 signaling has been associated with inflammatory bowel diseases. In this context CARD9 interacts with other immune proteins like NOD2 to modulate intestinal inflammation. Understanding CARD9’s role helps in elucidating its potential as a therapeutic target for managing these diseases.