Abcam, ab133715, Anti-NDRG3 antibody [EPR9011(B)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal NDRG3 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9011(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please
contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NDRG3 also known as N-Myc downstream-regulated gene 3 is a protein that acts as a stress-responsive molecule. Its molecular mass is approximately 41 kDa. Mechanically NDRG3 functions by interacting with other cellular pathways to ensure a proper stress response. The protein is widely expressed in various tissues with notable expression in the heart skeletal muscle and kidney. NDRG3 plays significant roles in cellular processes by modulating pathways in response to changes in the oxygen levels and nutrient availability.
Biological function summary
NDRG3 participates in processes that involve cell proliferation and differentiation and it can influence tumorigenic behavior. It is not part of a complex but interacts with other signaling molecules to exert its biological functions. NDRG3 responds to hypoxic conditions by stabilizing hypoxia-inducible factor (HIF)-1α promoting cell survival and adaptation under low oxygen availability. This capability makes it an important factor in cell adaptability under stress conditions.
Pathways
Four significant ones connect to NDRG3's involvement including the hypoxia response pathway and the MAPK/ERK signaling pathway. NDRG3 interacts closely with proteins like HIF-1α within the hypoxia response. In the MAPK/ERK pathway it influences downstream signals impacting cellular growth and differentiation. These interactions suggest that NDRG3 is integral to maintaining cellular homeostasis in environmental stress scenarios.
NDRG3 links to cancer progression and ischemic disorders. Its involvement in stabilizing HIF-1α connects it to cancer as the protein supports tumor growth and metastatic potential under hypoxic conditions often found in tumors. Similarly it relates to ischemic conditions in tissues like the heart where it helps regulate cellular responses to oxygen deprivation. Connections to proteins like HIF-1α in these cases highlight NDRG3's potential as a therapeutic target in managing these disorders.