Abcam, ab134043, Anti-FGFR1 alpha (phospho Y654) antibody [EP843(2)]

Size: 100µL
Rabbit Monoclonal FGFR1 phospho Y654 antibody. Suitable for WB, I-ELISA, Dot and reacts with Recombinant fragment - Human, Synthetic peptide - Human, Synthetic peptide samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP843(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, Dot, I-ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:This antibody recognizes FGFR1 (phospho Y654), FGFR2 (phospho Y657), FGFR3 (phospho Y648) and FGFR4 (phospho Y643).

Product details:
Species reactivity
Human, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please
contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FGFR1 alpha also known as Fibroblast Growth Factor Receptor 1 is a transmembrane protein with a mass of approximately 104 kDa. It functions as a receptor tyrosine kinase that mediates phosphorylation events when it binds to its ligand the fibroblast growth factors. Upon activation FGFR1 alpha undergoes dimerization and autophosphorylation on specific tyrosine residues. FGFR1 alpha is widely expressed in tissues like the brain lungs and kidneys indicating its involvement in diverse physiological processes.
Biological function summary
The FGFR1 alpha acts as a significant regulator of cell differentiation proliferation and survival. It forms part of a complex network that is critical in tissue development and homeostasis. The interactions of FGFR1 alpha with its ligands can activate several downstream signaling pathways that influence cell behavior. Its role in neural tissue development is particularly important as it supports early neuronal differentiation and survival.
Pathways
FGFR1 alpha features prominently in the MAPK/ERK and PI3K/AKT signaling cascades. These pathways manage essential cellular functions such as growth metabolism and apoptosis. FGFR1 alpha works closely with other receptors and proteins like SHC and GRB2 which propagate signals through these pathways to achieve precise cellular outcomes. These interactions exemplify the receptor’s embeddedness in tightly regulated signaling networks vital for maintaining cellular functions.
FGFR1 alpha mutations and aberrant signaling correlate with conditions such as cancer and skeletal developmental disorders. In particular it has connections to syndromes like Pfeiffer syndrome where FGFR1 mutations lead to cranial deformities. In cancer FGFR1 alpha may partner with oncogenic proteins like FRS2 facilitating a microenvironment conducive to tumor proliferation and angiogenesis. Understanding these relationships assists in identifying therapeutic targets and developing interventions for FGFR1 alpha-related conditions.