Abcam, ab134054, Anti-Mu Opioid Receptor antibody [UMB3] - C-terminal

Size: 20µL / 100µL / 1mL
Anti-Mu Opioid Receptor antibody [UMB3] - C-terminal (ab134054) is a rabbit monoclonal antibody detecting Mu Opioid Receptor in Western Blot . - Biophysical QC for unrivalled batch-batch consistency - Over 40 publications
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:UMB3,
Isotype:IgG,
Carrier free:No,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:The antibody detects the band of interest in transfected cell lines. When tested in our lab, we were not able to detect any signal from the endogenous protein.This antibody can be used in IHC and ICC/IF as demonstrated in several publications, however, it did not pass our internal validation in these applications. Please refer to PMID 20851148, 21957251, 26290245, and other references.

Product details:
What is this antibody validated in?
Anti-Mu Opioid Receptor antibody [UMB3] - C-terminal (ab134054) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB).
What is the molecular weight of Mu Opioid Receptor?
Anti-Mu Opioid Receptor [UMB3] - C-terminal (ab134054) specifically detects a band for Mu Opioid Receptor (UniProt: P35372) at a molecular weight of 45kDa.
Trusted by the scientific community
Anti-Mu Opioid Receptor [UMB3] - C-terminal (ab134054) was first used in a scientific publication in 2012 and has been cited over 40 times in peer-reviewed journals.
Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.
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Other related products
We have a range of other formats of antibody clone [UMB3] also available for your convenience: ab134054, Carrier free -
ab227067
, Carrier free -
ab271900
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Mu Opioid Receptor also known as MOR mu receptor or mu opiate receptor represents an important protein involved in pain and reward mechanisms. It is a G-protein coupled receptor with a mass of approximately 45 kDa. This receptor shows broad expression in the central nervous system with significant presence in areas such as the brainstem thalamus and spinal cord. MORs have a high affinity for endogenous opioids such as endorphins as well as exogenous opioid drugs like morphine.
Biological function summary
The Mu Opioid Receptor plays an essential role in modulating pain perception and response to opioids. It interacts predominantly with inhibitory G-proteins reducing neuronal excitability by decreasing cAMP levels and increasing potassium ion conductance. MORs are part of opioid receptor family which also includes delta and kappa receptors forming a complex regulatory system for the opioid signaling pathways. These receptors also modulate the release of neurotransmitters like GABA and dopamine.
Pathways
Signaling through the Mu Opioid Receptor integrates with the analgesic and reward pathways. It is important in the pain modulation pathway where it influences the perception of and response to pain stimuli. MORs interact with proteins such as adenylate cyclase and beta-arrestin which mediate desensitization and down-regulation processes. This interaction can also modulate the activity of dopamine pathways further linking MOR to reward and addiction mechanisms.
The Mu Opioid Receptor is closely connected to conditions like addiction and chronic pain. Anomalies in MOR function or expression can lead to an increased risk of opioid addiction due to its pivotal role in the reward pathway. Additionally chronic pain conditions might involve altered MOR signaling or density impacting pain management. Understanding MOR interactions with proteins like dopamine receptors can provide deeper insights into Huntington's disease and the role of opioid receptors in its pathology.