Abcam, ab13496, Anti-Alpha B Crystallin antibody [1B6.1-3G4]

Size: 100µg
Anti-Alpha B Crystallin antibody [1B6.1-3G4] (ab13496) is a mouse monoclonal antibody detecting Alpha B Crystallin in Western Blot, Flow Cytometry, IHC-P . Suitable for Cow, Human . - Over 50 publications - Trusted since 2004
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:1B6.1-3G4,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human, Cow,
Applications:ICC, Flow Cyt, WB, IHC-Fr, IHC-P, IHC-FrFlSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Native Full Length Protein corresponding to Cow CRYAB.P02510

Product details:
What is this antibody validated in?
Anti-Alpha B Crystallin antibody [1B6.1-3G4] (ab13496) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P) in Cow, Human samples.
What is the molecular weight of Alpha B Crystallin?
Anti-Alpha B Crystallin [1B6.1-3G4] (ab13496) specifically detects a band for Alpha B Crystallin (UniProt: P02510) at a molecular weight of 21kDa.
Trusted by the scientific community
Anti-Alpha B Crystallin [1B6.1-3G4] (ab13496) was first used in a scientific publication in 2004 and has been cited over 50 times in peer-reviewed journals.
Reviewed by scientists
Anti-Alpha B Crystallin [1B6.1-3G4] (ab13496) has over 5 independent reviews from customers.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.2Preservative: 0.09% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Alpha B Crystallin also known as CRYAB or alpha B crystallin protein is a small heat shock protein with a molecular mass of approximately 20 kDa. It is expressed in various tissues including the eye lens heart skeletal muscles and the brain. Alpha B Crystallin functions mechanically as a chaperone helping to prevent the aggregation of unfolded proteins by stabilizing them. This protein plays an important role in maintaining proper cellular function especially under stress conditions.
Biological function summary
Alpha B crystallin performs as part of the larger small heat shock protein family which contributes to the cellular defense system. It acts primarily as a chaperone binding to denatured proteins to protect the cells from damage during environmental stresses such as heat and oxidative stress. Alpha B crystallin often forms oligomeric complexes which increases its protective properties. This protein exhibits significant anti-apoptotic functions by interacting with various apoptosis-regulating factors contributing to cellular survival.
Pathways
Alpha B crystallin integrates into the cellular stress response and apoptosis pathways. It involves the PI3K/Akt signaling pathway known for regulating cell survival and preventing programmed cell death. Alpha B crystallin also interacts with other proteins such as Bcl-2 further enhancing its role in anti-apoptotic activities. Its contribution to these pathways highlights its protective function during cellular stress situations.
Alpha B crystallin is associated with cataracts and dilated cardiomyopathy. It plays a significant role in maintaining lens transparency and mutations or dysfunctions in alpha B crystallin can lead to cataract development. Similarly in cardiac tissue abnormal alpha B crystallin expression links to dilated cardiomyopathy. The protein is also known to associate with other structural proteins like desmin where disruptions may contribute to muscle-related diseases.