Abcam, ab134964, Anti-CHM antibody [EPR7142]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal CHM antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7142,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The CHM gene encodes for the Rab escort protein-1 (REP-1) which plays an essential role in the prenylation of Rab proteins a type of small GTPases involved in vesicle trafficking. The protein has a molecular mass of approximately 90 kDa. CHM is expressed in multiple tissues including the retina and nervous system. The alternate names for this protein include component of choroideremia and TCD which reflects its connection to cellular trafficking and transport processes.
Biological function summary
CHM is integral to the prenylation process which is important for anchoring Rab proteins to cellular membranes. Rab escort protein-1 acts within the Rab geranylgeranyltransferase complex facilitating the transfer of lipid groups to Rab proteins. This modification is necessary for proper Rab function affecting intracellular vesicle trafficking and membrane dynamics. CHM's biological actions are critical to cellular processes such as endocytosis exocytosis and autophagy.
Pathways
The CHM protein influences key cellular pathways such as the intracellular vesicle transport pathway and the autophagy pathway. Within these pathways CHM closely interacts with Rab proteins including Rab1 and Rab27 that are important in regulating vesicle movement within cells. The association of CHM with these pathways highlights its role in maintaining cellular transport and recycling mechanisms.
CHM is strongly linked to choroideremia a genetic disorder leading to progressive vision loss. Mutations in the CHM gene disrupt the normal function of REP-1 affecting the prenylation of Rab proteins and impairing cellular processes in the retina. Additionally CHM mutations can have implications in disorders related to X-linked inheritance. Research also connects CHM with pathogenic proteins like Rab27 linked to granule release disorders highlighting the impact of its malfunction in disease development.