Abcam, ab134970, Anti-ZPR1 antibody [EPR7595]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ZPR1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7595,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZPR1 also known as Zinc finger protein 1 is a protein weighing approximately 54 kDa. This protein mainly exists in the cytoplasm and nucleus of cells. ZPR1 interacts with the survival motor neuron (SMN) protein and cellular growth factors playing key roles in signal transduction and cellular proliferation processes. Its expression is highly regulated in a variety of tissues including brain liver and muscle.
Biological function summary
The actions of ZPR1 extend beyond simple binding interactions. ZPR1 assists in the formation and stability of SMN protein complexes critical for the assembly of small nuclear ribonucleoproteins (snRNPs). The protein is essential for proper localization of SMN in the nucleus a function that supports RNA splicing machinery maintenance. ZPR1 acts together with other constituents ensuring cellular communication and growth.
Pathways
ZPR1 operates mainly in pathways related to signal transduction and RNA processing. ZPR1 interacts in the PI3K/AKT pathway which is significant for cell growth and survival. Additionally the protein is linked to the TGF-beta signaling pathway impacting cell differentiation and tissue homeostasis. These interactions involve related proteins such as GRB2 and SMAD3 which further integrate ZPR1's role in these pathways.
The impairment of ZPR1 function shows relevance to neurodegenerative diseases specifically spinal muscular atrophy (SMA). This connection arises from its interaction with the SMN protein which is deficient in SMA patients. Additionally alterations in ZPR1 activity may contribute to certain cancer types due to its influence on cell proliferation pathways. Its pathway associations make ZPR1 a subject of interest in disease research linking to proteins involved in oncogenic processes like PI3K.