Abcam, ab136451, Anti-PER1 antibody - N-terminal

Size: 50µL
Rabbit Polyclonal PER1 antibody. Suitable for WB and reacts with Human samples. Cited in 13 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PER1 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PER1 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.O15534

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Preservative: 0.05% Sodium azide, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The PER1 protein also known as Period Circadian Protein Homolog 1 forms part of the circadian rhythm machinery. It has a molecular weight of approximately 136 kDa. This protein is expressed in various tissues including brain liver and muscle cells. Mechanically PER1 modulates the oscillations in the expression of core circadian clock genes. By binding to DNA PER1 regulates transcription and sets circadian rhythms stabilizing the biological clock.
Biological function summary
The PER1 protein plays a critical role in maintaining the body’s circadian cycles. It is part of a larger circadian clock complex that includes other components such as CLOCK and BMAL1. This protein ensures proper timing of sleep-wake cycles hormone release and other physiological processes. Although PER1 works with other proteins its individual expression influences the pace of the biological clock.
Pathways
PER1 protein functions within the circadian rhythm pathway and impacts the regulation of the sleep-wake cycle. It interacts with the CLOCK and CRY proteins contributing to the transcription-translation feedback loop fundamental for circadian timing. This complex interplay helps maintain synchronization with environmental light-dark cycles affecting various biological processes.
Abnormalities in PER1 expression associate with sleep disorders like familial advanced sleep phase syndrome (FASPS) and certain mood disorders. Disruptions in its regulatory network involving proteins like PER2 can lead to misalignments in circadian rhythms. These changes can result in issues with sleep patterns and contribute to mood regulation problems.