Abcam, ab136702, Recombinant Human TRAPPC2 protein

Size: 20µg
Recombinant Human TRAPPC2 protein is a Human Full Length protein, in the 1 to 140 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>90% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P0DI81,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 40% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRAPPC2 also known as sedlin is a component of the transport protein particle (TRAPP) complex with a molecular mass of approximately 17 kDa. It is a small protein that has a significant role in vesicular trafficking within cells. TRAPPC2 is expressed widely in human tissues with notable levels in the testis skeletal muscle and heart. This protein participates in the regulation of intracellular transport processes by assembling into multi-subunit complexes that facilitate the movement of vesicles.
Biological function summary
TRAPPC2 plays a role in the formation and function of the TRAPP complex which is fundamental for intracellular vesicle trafficking. The TRAPP complex exists in different forms and participates in the tethering of vesicles to target membranes. TRAPPC2’s involvement in this complex influences ER-Golgi transportation impacting how proteins and lipids move inside cells. By working as part of the TRAPP complex TRAPPC2 contributes to the maintenance of cellular homeostasis by controlling the flow and direction of cargo.
Pathways
TRAPPC2 is involved in the secretory pathway which is essential for protein sorting and transport. It interacts with other TRAPP subunits such as TRAPPC3 and TRAPPC9 to ensure effective vesicle fusion and trafficking processes. In addition to the secretory pathway TRAPPC2 is engaged in the autophagy pathway. Through its participation in these pathways TRAPPC2 affects how cells manage and recycle cellular components under varying conditions.
Mutations in TRAPPC2 are linked to X-linked spondyloepiphyseal dysplasia tarda a skeletal disorder affecting bone growth and development. The deficiency of TRAPPC2 disrupts normal vesicular trafficking ultimately leading to the symptoms observed in this disorder. TRAPPC2’s interactions with proteins such as TRAPPC3 and TRAPPC9 through these pathways underline its significance in maintaining cellular functions that when altered result in specific pathological states.