Abcam, ab137075, Anti-NCAPD2 antibody [EPR9220]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal NCAPD2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9220,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NCAPD2 also known as condensation protein complex subunit 2 is a part of the condensin I complex and is important for chromosome assembly and segregation during mitosis. With an approximate molecular mass of 150 kDa NCAPD2 functions as a regulatory unit within this complex. Researchers find NCAPD2 expression highest in proliferating cells especially in tissues with active cell division such as the bone marrow and some epithelial tissues.
Biological function summary
NCAPD2 plays a significant role in maintaining chromosomal architecture during cell division. It is a part of the condensin I complex which is required for the proper condensation and stabilization of chromatids through the cell cycle. NCAPD2 interacts with other proteins within the complex such as SMC2 and SMC4 to ensure efficient DNA packaging and separation aiding in genomic stability.
Pathways
NCAPD2 is heavily involved in the cell cycle control specifically during mitosis. Its role in these pathways ensures the accurate distribution of genetic material to daughter cells. Within the cell cycle pathway NCAPD2 associates with other proteins like topoisomerase II and aurora B kinase which are important for chromosomal segregation and cytokinesis.
NCAPD2 dysregulation links to cancer and congenital malformation syndromes. Abnormal function or expression of NCAPD2 might contribute to faulty chromosome condensation leading to genomic instability a hallmark of many cancers. Additionally mutations affecting NCAPD2 and its interaction partners like SMC2 might lead to developmental disorders characterized by structural chromosome anomalies.