Abcam, ab137077, Anti-ADH4 antibody [EPR9483]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ADH4 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9483,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ADH4 also known as alcohol dehydrogenase 4 is an enzyme with a mass of approximately 40 kDa. This enzyme plays a role in the oxidation of alcohols within the digestive system. Not just limited to the digestive system ADH4 also shows expression in the liver and kidneys where it contributes to the metabolic processes. Its action involves converting ethanol and other alcohols to their corresponding aldehydes which are then further metabolized.
Biological function summary
The enzyme participates in the oxidation of retinol to retinoic acid a process essential for diverse biological functions. While ADH4 operates primarily as a standalone enzyme it still interacts with other members of the alcohol dehydrogenase family within the liver. These interactions facilitate intermediary metabolism and help maintain homeostasis. The enzyme's role extends beyond simple alcohol metabolism implicating it in broader metabolic contexts.
Pathways
ADH4 occupies a definite position in the ethanol metabolism pathway. It cooperates with enzymes like aldehyde dehydrogenase to process ethanol into acetic acid a step important for energy production and detoxification. Additionally its activity relates to the retinoic acid signaling pathway. Through this pathway it interacts indirectly with enzymes that process retinoids connecting it to cellular differentiation and vision.
ADH4 has associations with alcohol-related liver disease and fetal alcohol syndrome. In liver disease ADH4's excessive ethanol oxidation can lead to toxic aldehyde accumulation contributing to tissue damage. Its interaction with aldehyde dehydrogenase becomes significant as any dysfunction in this relation might exacerbate disease severity. Moreover disruptions in retinoic acid metabolism where ADH4 plays a part can link to disorders affecting embryonic development highlighting its role in conditions like fetal alcohol syndrome.