Abcam, ab137080, Anti-TROY antibody [EPR3214(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TROY antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR3214(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The TROY protein also known as TNFRSF19 is a member of the tumor necrosis factor receptor superfamily. It has a molecular mass of approximately 42 kDa. TROY is mainly expressed in the central nervous system particularly in brain tissue but researchers also detect it in certain peripheral tissues. The protein contains an extracellular domain a single transmembrane segment and a cytoplasmic domain that interacts with other intracellular signaling proteins. These structural components allow it to function effectively in signal transduction throughout the cells.
Biological function summary
TROY protein plays a significant role in the central nervous system's development and maintenance. It interacts with components of the neurotrophin signaling pathway including p75 neurotrophin receptor to influence neuronal survival and differentiation. TROY does not function alone; it is part of receptor complexes that modulate various intracellular pathways. Its interactions with ligands like Nogo receptor and LINGO-1 indicate its involvement in restricting neuronal growth impacting axon regeneration and central nervous system repair processes.
Pathways
The TROY protein integrates into neurotrophin signaling and axon guidance pathways. In neurotrophin signaling it affects cellular response to growth factors essential for neural growth and survival. In axon guidance TROY impacts cellular navigation cues that direct axon growth. This protein interacts closely with other molecules such as the Nogo receptor which often collaborates in signaling cascades that influence these pathways. These interactions underline TROY's contribution to maintaining the delicate balance of neuronal connections.
TROY protein has links to neurodegenerative disorders like Alzheimer's disease and multiple sclerosis. Alzheimer's disease research shows that TROY might influence amyloid-beta peptide interactions exacerbating neuronal degradation processes. Similarly in multiple sclerosis the protein's role in inhibiting axon regrowth makes it a potential target for therapeutic intervention. TROY's interaction with proteins such as p75 and Nogo receptor highlights its influence on disease progression by mediating cellular processes that relate to neurodegeneration and neuron damage response.