Abcam, ab137103, Anti-NAT14 antibody [EPR9376]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal NAT14 antibody. Suitable for WB and reacts with Human, Mouse samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9376,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NAT14 also known by its alternate name "N-acetyltransferase 14" functions as an enzyme facilitating acetylation processes. With a molecular mass of approximately 65 kDa NAT14 localizes mainly in the cytoplasm of human cells. Researchers have noted that it expresses significantly in tissues such as liver and kidney. Through its mechanical role NAT14 plays an important part in transferring acetyl groups to substrate molecules serving an important function in the regulation of several metabolic processes.
Biological function summary
NAT14 influences cellular metabolism by modulating protein function through acetylation. Although no direct association with a large complex is reported NAT14's acetyltransferase activity contributes to regulatory pathways involving small molecules and proteins. These pathways can significantly affect cellular growth stress responses and detoxification where proper acetylation is necessary for maintaining cellular homeostasis.
Pathways
Investigators recognize NAT14's role in the acetyl-CoA biosynthesis and protein acetylation pathways. In these pathways NAT14 maintains close interaction with proteins like NAT1 which also partake in acetylation activities. Such pathways are critical in cellular metabolism and influence various downstream biological processes including gene regulation and signal transduction.
NAT14's activity relates closely to conditions such as metabolic disorders and certain liver diseases. Changes in its activity could lead to disrupted acetylation balance linking it to dysregulation observed in these diseases. Furthermore researchers have also studied its interaction with proteins like p300 a well-known acetyltransferase in the context of hepatic disease states. The collective findings highlight NAT14's relevance in disease mechanisms aiding potential therapeutic explorations.