Abcam, ab137173, Recombinant Human LIN7C protein

Size: 100µg
Recombinant Human LIN7C protein is a Human Full Length protein, in the 1 to 197 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>90% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9NUP9,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 30% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LIN7C also known as Lin-7 homolog C or Veli3 is a protein associated with the regulation of cellular processes. This protein weighs approximately 24 kDa and is expressed in various tissues including the brain and epithelial cells. LIN7C belongs to the LIN-7 family characterized by their PDZ domains which are important for protein-protein interactions. The protein plays a significant role in maintaining cell polarity which is essential for the proper functioning of cells in different tissue types.
Biological function summary
LIN7C contributes significantly to cellular signaling and organization. It operates as part of a multiprotein complex alongside DLG1 and CASK interacting with several other proteins to facilitate cell adhesion and synaptic transmission. This assembly orchestrates the anchoring of membrane proteins influencing the spatial distribution of signaling receptors. LIN7C's role ensures that proteins reach and maintain their proper membrane location important for successful synaptic and epithelial cell functioning.
Pathways
LIN7C is actively involved in the PI3K/AKT pathway critical for cell survival and proliferation. LIN7C assists in stabilizing interactions with signaling molecules like GRIN2B contributing to synaptic plasticity and memory formation. Additionally LIN7C engages with the Wnt signaling pathway which influences cell development and differentiation through interactions with proteins such as LRP6. This interaction emphasizes LIN7C's importance in processes that guide cellular growth and differentiation.
LIN7C has connections to neurological conditions such as autism spectrum disorders and schizophrenia. Its involvement in maintaining synaptic stability and neurotransmission links it to these disorders often characterized by synaptic dysfunction. Moreover dysregulation of LIN7C affects interactions with proteins such as DLG4 contributing to the pathophysiology of these conditions. Understanding LIN7C’s role offers insight into potential therapeutic targets for mitigating synaptic-related dysfunctions seen in these neuropsychiatric disorders.