Abcam, ab137716, Anti-Cdk7 antibody

Size: 100µL
Rabbit Polyclonal CDK7 antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CDK7 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CDK7 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P50613

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cyclin-dependent kinase 7 (Cdk7) also known as CAK is a protein that functions as a serine/threonine kinase. It has a mass of approximately 37 kDa and is expressed in various tissues including the liver heart and testis. Cdk7 forms part of the CDK-activating complex required for the cell cycle's progression and transcription processes. By phosphorylating important sites on target proteins Cdk7 contributes to the regulation of the cell cycle and RNA polymerase II-mediated transcription.
Biological function summary
Cdk7 interacts with other molecules playing a fundamental role in the regulation of cell division and transcription. Cdk7 is a component of the Cdk-activating kinase (CAK) complex alongside cyclin H and MAT1. This complex enables activation of other cyclin-dependent kinases through phosphorylation which is essential for DNA replication and repair. As part of the transcription complex TFIIH Cdk7 enhances RNA polymerase II's transcriptional activity influencing gene expression and cellular responses to external signals.
Pathways
Cdk7 participates in significant regulatory pathways controlling cell cycle and transcription. It is integral to the p53 Signaling and Cell Cycle pathways where it facilitates the activation of CDK1 CDK2 and CDK4/6 key players in cell cycle progression from the G1 to S phase. Through these pathways Cdk7 maintains cellular control upon environmental stress responses and DNA damage providing connections to tumor suppressor proteins such as p53.
Cdk7 has associations with cancer and neurodegenerative diseases. Its dysregulation can lead to unchecked cell proliferation contributing to the development of various cancers like breast and lung cancer. Cdk7's role in transcription implicates it in disorders like Alzheimer's disease where altered transcriptional regulation is observed. Furthermore its interaction with proteins such as p53 links it to cancer as p53 mutations can result in the loss of control over the cell cycle exacerbating tumorigenic processes.