Abcam, ab139191, Anti-CCDC98 antibody [EPR6310(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal CCDC98 antibody. Suitable for IP, WB, ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 11 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR6310(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, Flow Cyt (Intra), ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CCDC98 also known as NABP2 or MERIT40 functions as a protein that assists in the DNA damage response and repair pathways. Its molecular mass is approximately 42 kDa. CCDC98 primarily shows expression in the nucleus of cells. It is essential in repair processes by interacting with other proteins involved in the DNA double-strand break repair mechanism. The protein ensures stability within the BRCA1-A complex playing a role in maintaining genomic integrity.
Biological function summary
CCDC98 supports cellular processes by stabilizing the BRCA1-A complex which is important for the homologous recombination repair of damaged DNA. This protein forms an important part of the machinery that recognizes and processes DNA damage. It interacts with other core components of the DNA repair system like BRCA1 RAP80 and ABRAXAS ensuring efficient repair and prevention of genomic instability.
Pathways
CCDC98 is integral to the homologous recombination repair and cell cycle checkpoint pathways. Through its association with the BRCA1-A complex CCDC98 influences the recruitment and retention of repair proteins at DNA damage sites a critical event in the DNA damage response pathway. It connects with other proteins such as BRCA1 and RAP80 to regulate repair pathway activities and proper cell cycle progression reinforcing cellular responses to DNA damage.
CCDC98 is linked to breast and ovarian cancers. Mutations or dysregulation affecting CCDC98's function can disrupt BRCA1-A complex stability leading to compromised DNA repair ability which is a factor in tumorigenesis. It connects to the BRCA1 protein in these disease contexts where impaired interactions can raise the risk of developing cancer showcasing the significance of this protein in health and disease contexts.