Abcam, ab139806, Anti-SHQ1 antibody

Size: 100µL
Rabbit Polyclonal SHQ1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Protein SHQ1 homolog.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Protein SHQ1 homolog. The exact immunogen used to generate this antibody is proprietary information.Q6PI26

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SHQ1 is a protein involved in the processing and maturation of small nucleolar RNAs (snoRNAs). Also known as HSPC037 it has a molecular mass of approximately 65 kDa. SHQ1 is expressed in various tissues with its highest expression in the heart and skeletal muscle. It interacts directly with H/ACA ribonucleoproteins playing a role in the assembly and stability of these complexes which are essential for proper ribosome biogenesis.
Biological function summary
SHQ1 influences the proper assembly of H/ACA snoRNPs complexes important for the modification and maturation of ribosomal RNA (rRNA). SHQ1 primarily assists in the stabilization and assembly of dyskerin a catalytic subunit within H/ACA snoRNP complexes. Its function ensures accurate pseudouridylation a process that facilitates proper folding and functionality of rRNA within the ribosome. The protein's interaction within these complexes highlights its role in maintaining ribosomal integrity and function.
Pathways
The importance of SHQ1 lies within the snoRNA processing and ribosome assembly pathways. It plays a part in the ribosome biogenesis pathway which is vital for efficient protein synthesis. SHQ1 associates with dyskerin and other snoRNP proteins such as NOP10 and NHP2 linking them to the successful modification of rue rRNA. By influencing these interactions SHQ1 is integral to the proper synthesis and function of ribosomes.
Mutations or dysregulation of SHQ1 have been associated with disorders like X-linked Dyskeratosis Congenita and certain cancers. In Dyskeratosis Congenita defects in ribosome function arise due to inadequate rRNA pseudouridylation in which SHQ1 plays a significant part. Additionally anomalous expression of SHQ1 can lead to aberrant cell growth associating it with oncogenesis and tumor development. This connection to proteins such as dyskerin emphasizes the impact of SHQ1 in maintaining cellular health and its potential role in disease pathogenesis.