Abcam, ab140188, Anti-RILP antibody

Size: 100µL
Rabbit Polyclonal RILP antibody. Suitable for WB and reacts with Mouse samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human RILP.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human RILP. The exact immunogen used to generate this antibody is proprietary information.Q96NA2,
Specificity:At least two isoforms of RILP are known to exist; ab140188 will only detect the longer isoform.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RILP known as Rab-interacting lysosomal protein is a critical component in the regulation of membrane trafficking. The protein weighs approximately 45 kDa. RILP assists in tethering and fusion processes essential for vesicle transport acting as an effector for the small GTPase Rab7. It is mainly expressed in the lysosomal compartments of cells. By binding to Rab7 RILP influences endocytic trafficking by coordinating microtubule-based movement of endosomes and lysosomes.
Biological function summary
RILP collaborates within multiprotein complexes influencing lysosomal positioning and maturation. It mediates recruitment of dynein-dynactin motor complexes allowing effective transport of lysosomes along microtubules. Furthermore RILP's activity impacts the degradation pathway assisting in the clearance of cellular debris and turnover of cellular components. It interacts with various cellular structures to maintain the balance between movement and stability of lysosomes which is essential for cellular homeostasis.
Pathways
Researchers place RILP within significant cellular processes like lysosome positioning and autophagic pathways. Its role is important in the endocytic pathway where it acts with proteins like Rab7 and the retromer complex. RILP governs endosome-to-lysosome trafficking impacting cargo sorting and turnover. It shares functional interactions with proteins involved in autophagy influencing the delivery of cellular components for degradation within lysosomes.
RILP notably connects to neurodegenerative diseases and cancers. Altered RILP function can disrupt lysosome positioning and trafficking leading to disorders like Niemann-Pick disease type C. In cancer RILP's interaction with key signaling proteins contributes to tumor progression and metastasis. The protein's regulatory effects on lysosomal pathways intersect with various cellular processes including those involving proteins such as Rab7 that when dysregulated result in pathological conditions.