Abcam, ab140435, Anti-Nexilin/F-actin-binding protein antibody

Size: 100µg
Rabbit Polyclonal Nexilin/F-actin-binding protein antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human NEXN aa 200-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NEXN aa 200-250. The exact immunogen used to generate this antibody is proprietary information.Q0ZGT2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab140435 was affinity purified using an epitope specific to Nexilin/F-actin-binding protein immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Nexilin also known as F-actin-binding protein serves vital role in the mechanical stability of cells. It binds to actin filaments reinforcing structural integrity important for muscle function. Nexilin has a molecular mass around 75 kDa. This protein sees expression mainly in cardiac and skeletal muscle tissues. Actin-binding proteins like nexilin stabilize the actin cytoskeleton which is important for maintaining structure of muscle cells during contraction and relaxation.
Biological function summary
Nexilin contributes significantly to maintaining the integrity of muscle cells. It stabilizes actin filaments in sarcomeres which are the basic units of muscle contraction. Nexilin forms part of a complex that interacts with other structural proteins like actin-binding proteins which together help preserve cellular architecture under mechanical stress. This function is essential for normal heart muscle function and response to mechanical load.
Pathways
Nexilin plays a role in cardiac muscle contraction and signal transduction pathways. The protein integrates into the myofibril assembly process ensuring efficient communication within muscle cells. Pathways involving nexilin link with proteins such as titin assisting with elasticity and tension. These pathways maintain cardiac function under mechanical strain reflecting nexilin's actin-binding protein role in muscle physiology.
Mutations or dysfunctions in nexilin connect to dilated cardiomyopathy and other cardiac diseases. Abnormal nexilin expression affects structural stability leading to heart muscle weakness. The link with proteins like desmin a cytoskeletal protein associates nexilin to these conditions. Understanding nexilin’s interactions could offer insights into heart disease treatment emphasizing its importance in cardiovascular health.