Abcam, ab140649, Anti-HEXB antibody [EPR7978]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal HEXB antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 8 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7978,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The target known as HEXB also called Hexosaminidase subunit beta consists of protein subunit that helps in the formation of the enzyme beta-hexosaminidase. This enzyme is active in lysosomes and it weighs about 63 kDa. Beta-hexosaminidase functions to break down GM2 gangliosides which are molecules in cell membranes. HEXB expresses mainly in the brain and liver tissues signaling its role in neurological and hepatic processes.
Biological function summary
The beta-hexosaminidase enzyme formed by HEXB participates in the lysosomal degradation pathway. This enzyme requires formation of a complex with its counterpart HEXA to become biologically active. Together they catalyze the hydrolysis of GM2 gangliosides into GM3 gangliosides which is an essential step for cell membrane metabolism. This process is important for maintaining cellular homeostasis and preventing accumulation of toxic substances within cells.
Pathways
The HEXB encoded enzyme participates in sphingolipid metabolism an integral component of lipid metabolic pathways. Sphingolipids are part of many cellular functions including signal transmission and cell recognition. HEXB through the lysosomal degradation of gangliosides works closely with HEXA and NEU1 which further processes GM3 gangliosides into simpler molecules. Such interactions underline HEXB’s significant role in maintaining the balance of lipid metabolism within cells.
Mutations or deficiencies in HEXB lead to serious genetic conditions such as Sandhoff disease. This disorder results from the improper breakdown of gangliosides due to the lack of functional HEXB leading to their accumulation which severely damages nerve cells and results in neurological impairments. The partnership between HEXB and HEXA emphasizes the importance of both subunits as malfunction in either can contribute to disease progression by disrupting normal ganglioside metabolism.